The influence of calorie restriction during the Ramadan fast on serum fructosamine and the formation of beta hydroxybutirate in type 2 diabetes mellitus patients.

AIM To determine whether the Ramadan fasting can improve metabolic control evaluated from serum fructosamine and beta hydroxybutirate in patients with Type 2 diabetes mellitus. METHODS This was a prospective one group before and after study (self-controlled study). Twenty four patients from the outpatient clinic of the Metabolic Endocrinology Division of the Department of Internal Medicine, Faculty of Medicine, University of Indonesia/ Cipto Mangunkusumo General Hospital who were well under control underwent assessment for serum fructosamine at weeks -1, 4, and 6 (2 weeks after the Ramadan fast) and beta hydroxybutirate formation at week 4. RESULTS The mean serum fructosamine on weeks -1, 4, and 6 were 334.2 +/-45.7; 303.9 +/-34.5 dan 313.6 +/-45.9 umol/L. The beta hydroxybutirate level was 0.3 mmol/L. CONCLUSION The Ramadan fasting in patients with well-controlled and medium-controlled type 2 diabetes mellitus could cause a reduction in serum fructosamine and does not cause formation of beta hyroxybutirate.